This issue is part of the “Evolutionary War” crossover, so there’s also some hullabaloo with the High Evolutionary unfolding.
FANTASTIC FOUR ANNUAL #21: Before the FF can follow the trail of the Beyonders into the Negative Zone, Crystal is ordered to return home to her Inhuman family and her estranged husband Quicksilver. When she refuses, it’s the Fantastic Four vs. the Inhumans!
FANTASTIC FOUR #317: The FF are back on Earth, but not for long. They have to head across the galaxy with their new starfaring friends in search of the Beyonders. But first they have to deal with the treacherous Nuwali!
INCREDIBLE HULK #342: The team learns where the government is storing the Gamma bombs that they have been looking for, but before they can act on it, the Leader sends Half-Life to deal with the Hulk.
INCREDIBLE HULK #341: While visiting Clay Quartermain’s family, Hulk has to deal with the impending threat of the savage Man-Bull, who wants one of two things: to be cured, or to be killed.
Here’s Spider-Man envisioning Toad dressed up like Black Cat, and Frog-Man getting pissed on by a dog.
AMAZING SPIDER-MAN #265: Aging jewel thief the Fox has returned, and he just wants one last heist in order to retire; but the bounty Hunter organization known as Silver Sable, Inc. is on his tail, and Spider-Man has to intervene before things get out of hand.