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In a new APP knock-in mouse, plaques abound, neurites swell, tau/NfL collect in the CSF. Microglia bloat with lipids and rev up disease-associated gene transcription. The mice will be available for unrestricted use @Denalitx @jacksonlab https://t.co/7O6JXF7EYs
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Exosomes carrying misfolded tau depend on lysosomal dysfunction to seed aggregation. #alzheimersdisease @QldBrainInst https://t.co/hhkC1v5jnv
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