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"Wh...oh, a gun...so that was the loud report and burning sensation in my groin."
Hell, come to think of it, Nemesis's new 2nd form in the REmake is basically just Mr. X PS1 mutated form crossed with William Birkin's original 4th form (which was also changed in REmake 2)
...mad scientists, super powered villains, tokusatsu monsters, Cenobites...
Resident Evil has done: Haunted houses. Zombie apocalypses. ALIENS (the movie, not actual aliens...yet), THE TERMINATOR...