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Wondering how C9orf72 repeat expansion could contribute to the pathogenesis of multiple neurodegenerative diseases? Altering microglial function
#C9orf72 deficiency promotes microglial-mediated synaptic loss in aging & amyloid accumulation https://t.co/fsfGrwdNMk #ALS #FTD
Issue 19 adorned by images from @dralexswarbrick @sunnyz_wu et al & @TeamSciStories
Also featured: solution of a FAK conundrum; & review of plant retinoblastoma
plus: MICU1/2 structure, CARD8 inflammasome in T-cells, RNA exosome in C9orf72 FTLD/ALS …
https://t.co/7t2MUsbb6M
Issue 8 features #geranylgeranyl Golgi donations, transmission of pathogenic #C9orf72 in ALS/FTD, light-responsive #miRNA clearing retinal cells, and #Chlamydia rewiring host cell metabolism. @beatascienceart cover for Pei, Zheng and coworkers
https://t.co/2mJqgm3FMl