Wondering how C9orf72 repeat expansion could contribute to the pathogenesis of multiple neurodegenerative diseases? Altering microglial function

deficiency promotes microglial-mediated synaptic loss in aging & amyloid accumulation https://t.co/fsfGrwdNMk

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Issue 19 adorned by images from et al &
Also featured: solution of a FAK conundrum; & review of plant retinoblastoma
plus: MICU1/2 structure, CARD8 inflammasome in T-cells, RNA exosome in C9orf72 FTLD/ALS …
https://t.co/7t2MUsbb6M

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Issue 8 features Golgi donations, transmission of pathogenic in ALS/FTD, light-responsive clearing retinal cells, and rewiring host cell metabolism. cover for Pei, Zheng and coworkers
https://t.co/2mJqgm3FMl

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