Ceruminous gland adenoma: external ear canal, can be painful & cause hearing impairment🔬 Well defined with apocrine inner lining and outer myoepithelial layer. No overt cytologic atypia

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Carcinoma cuniculatum:
🔬rare type of well-diff SCC which shouldn't be confused with verrucous ca
🐇forms cystically dilated sinuses "the burrows of a rabbit warren"
🦶usually develops on soles
A while ago we proposed its criteria in AJD: 10.1097/DAD.0000000000001457

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Look at this high-grade cutaneous MPNST!

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Thursday special. 😆🔬

I could not let this go without sharing its morphologic beauty.

Sebaceoma

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20 yo woman. Thumb lesion. A perfect example! What is the diagnosis? Answer: https://t.co/ap5qa7YGWm. Video on how to tell it apart from a potential mimic: https://t.co/VgWjuYhRxV.

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He’s back! Biopsy from the chest of a 60+ year old woman. What do you think is going on here?

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36M Hx: lesion left temporal scalp ?BCC/??other. Any guesses?

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Moving on to some skin paintings the next days, 80/100 was inspired by a masson-goldner-trichrome.

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Happy Saturday! Show a really “not much” case, but turns out again be “very much” and serious. I saw these lesions daily, most are just solar lentigo or macular SK. But you have to be careful and use IHC generously. 66 cheek lentigo.#Dermpath

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☠️Case of The Day☠️
✅Compact hyperkeratosis
✅Focal parakeratosis and hypergranulosis
✅Irregular psoriasiform hyperplasia
✅Collagen bundles in papillary dermis

Choose your answer in the next tweet👇

Images:

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Think about foreign body (splinter in this case) when there’s extensive epidermal necrosis and intense acute inflammation

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Cellular neurothekeoma: solitary lesion, young age group, mostly females on the head&neck. Multilobular pattern in a fibrotic/hyalinized stroma, lobules composed of round cells with vesicular chromatin arranged in concentric nests that swirl w/ some mucin

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Diagnosis: Staph scalded skin syndrome. SSSS (not SJS/TEN). Detached stratum corneum w free floating acantholytic keratinocytes (key to dx!). If corneum missing look around slide to try to find it. No inflammation or bacteria (toxin mediated).

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Gottlieb’s sandwich sign: Fungal hyphae are “sandwiched” between two zones of cornified cells: orthokeratosis on top & parakeratosis or compact orthokeratosis below. Can be used as a clue for low power dx of dermatophyte infection.

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✔ this is a proliferating trichilemmal cyst:
📍proliferation of squamous cystic areas in dermis, lobular architecture.
📍stratified squamous epithelium with abrupt/trichilemmal keratinization.
📍rupture frequent.
📍malignant transformation is rare.
📍DDx with SCC

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