Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome (DRESS) involvig LN with AITL-like morphology:

🩸Dense infiltrate of polymorphic lymphocytes
🩸Preserved overall architecture: Adequate B & T-cell compartments (sign of benignancy)

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Definitely my favorite blood cell, eosinophil for 72/100

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thread Highlights from today's great session by

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An example of splenic marginal zone lymphoma (SMZL): Infiltration of the red and white pulp by neoplastic small B-cells,highlighted by CD20.Epithelioid histiocytes may be seen in the lymphoid aggregates in SMZL, as shown in this case

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My case of the month: older man found to have ⬆️ WBC due to ⬆️ lymphs (35x10e9/L). Asymptomatic, w/ imaging later showing mild splenomegaly and no LAD. PB images:

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40 yo male presenting pancytopenia and fever. Acute leukemia was suspected. After difficult aspirate we found...#HairyCellLeukemia

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Acute Promyelocytic Leukemia APML, micro-/hypo-granular variant. High TLC with abnormal promyelocytes (blast equivalents). Nuclei “coin-on-coin” bilobed or “angel-wing” appearance. No Auer rods. +ve for t(15;17) by FISH (no image).

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Chronic myeloid leukemia BCR-ABL1+ maturing neutrophils with “myelocyte bulge”, blasts usu <2%, inc basophils (arrow) blasts express myeloid antigens (CD13, CD33, CD117) and progenitor cell antigen (CD34, CD38, HLA-DR) plus CD123+ basophils

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