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Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome (DRESS) involvig LN with AITL-like morphology:

🩸Dense infiltrate of polymorphic lymphocytes
🩸Preserved overall architecture: Adequate B & T-cell compartments (sign of benignancy)

40 69
2023-02-21

Definitely my favorite blood cell, eosinophil for 72/100

11 68
2020-09-22

thread Highlights from today's great session by

18 36
2020-04-21

Young person with enlarged cervical LN. what immunostains would you order?

47 115
2020-03-23

66 yo F with L hip pain s/p trauma.

Hx: SOB, itchiness, hives, vomiting

AGGRESSIVE SYSTEMIC MASTOCYTOSIS

- CD25+, CD117+
- Kit Gene Exon 17 mutation+
- Spindle cells w/ granular cytoplasm
- Mast cells replacing marrow (causing Fx)

75 158
2020-03-06

Hairy cell case in a 34-year old male patient

🔬 PB smear (figures): mononuclear large lymphocytes with abundant cytoplasm and circumferential hair-like projections
💡 FC: CD19/CD20+++, CD305+, CD11c+, CD103+
🧬 Genetics: BRAF mutation V600E

101 255
2020-02-18

An example of splenic marginal zone lymphoma (SMZL): Infiltration of the red and white pulp by neoplastic small B-cells,highlighted by CD20.Epithelioid histiocytes may be seen in the lymphoid aggregates in SMZL, as shown in this case

31 80
2020-02-01

My case of the month: older man found to have ⬆️ WBC due to ⬆️ lymphs (35x10e9/L). Asymptomatic, w/ imaging later showing mild splenomegaly and no LAD. PB images:

24 43
2019-10-25

40 yo male presenting pancytopenia and fever. Acute leukemia was suspected. After difficult aspirate we found...#HairyCellLeukemia

47 117
2019-05-30

Acute Promyelocytic Leukemia APML, micro-/hypo-granular variant. High TLC with abnormal promyelocytes (blast equivalents). Nuclei “coin-on-coin” bilobed or “angel-wing” appearance. No Auer rods. +ve for t(15;17) by FISH (no image).

23 36
2018-12-23

Chronic myeloid leukemia BCR-ABL1+ maturing neutrophils with “myelocyte bulge”, blasts usu <2%, inc basophils (arrow) blasts express myeloid antigens (CD13, CD33, CD117) and progenitor cell antigen (CD34, CD38, HLA-DR) plus CD123+ basophils

49 72
2018-07-12