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.@mrbobodenkirk does the voice of Chaz, the mayor's aid in The Why of Fry. Check out those eyebrows.
Zoidberg salutes Nixon when he calls Planet Express because Matt Groening felt someone should react if the president calls.
In Love and Rockets, Bender mentions being a "cuddly baby tapir." Earlier, the Planet Express ship expressed her love of tapirs at the zoo, and they're also in the opening of 2001: A Space Odyssey which is a reference all over this episode.
There was a whole segment in Kif Gets Knocked up a Notch where he meets his family in the forest and has to go on a quest to find items for the birthing ritual that got cut. Bill Odenkirk says there was enough for a whole new episode.
The original line for "You call that a pressed ham?" was "You call that an anus?"
Mom's hair is supposed to look like Dracula in Coppola's Bram Stoker's Dracula
In Yo Leela Leela, Fry is seen playing a trombone and composer @christophertyng was asked to make it sound bad but not too bad. He actually brought in a highschool student to record a session but it sounded too bad for what they wanted. What we hear on the show is a synthesizer
The talking devil head tattoo Amy gets in Three Hundred Big Boys is in the style of @ARTofCOOP
One of the creatures Alcazar transforms into is a Yith from HP Lovecraft's A Shadow Out of Time