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Direction of the setting sun is consistent throughout the comic, and is in accordance with the map #ArtofLegends
You can track the passage of time based on Jayce's shirts/coat
You can find callback references (on a screen in this case) to events which happened before, and from the source's angle (security camera)
Almost all characters (especially in Piltover) have bright blue eyes. This is both part of the Piltover worldbuilding, and to create a contrast with the main character.
Backgrounds in Piltover are smooth and bright. Those in Zaun are suffocating, with grunge texture.
here's how far I've reached with Disco Viktor concept (whoops, Space Groove)
My silly webcomic Exper-elemental exceeded my expectations of how interesting it would be to people, and evolved into an absolute unit of a story!