Sergey Ovchinnikov 🇺🇦さんのイラストまとめ

Interesting... I suspect, by reducing the # of seqs in the MSA, this reduced the strength/certainty of restraints derived from coevolution, allowing AlphaFold to generate multiple hypotheses (conformations) with randomseed, model param, or msa pertubations https://t.co/3JPM8Ysgox

Glad to see this out! Minor contribution from my side. We tested to see how well AlphaFold can predict homo-oligomers and their oligomeric state. Here I'm plotting the min(pTMscore) across 5 models, splitting success (top row) and failures (bottom row). https://t.co/fhdMtC3f4L

Got a few requested for mis/matching symmetries support. Examples below for "8:1" (for two components of the ATP-synthase) and "2:2". Option now included in the latest notebook update! Tell me if you run into any errors.

Successfully predicted one of the @foldit denovo designs using #alphafold in google-colab😎 (1 model, no template, single sequence input, and no amber refine, ~2 mins). Notebook if anybody wanna try input your favorite sequence:
https://t.co/qaj7Ws9CtP