Older pt with malignancy who developed nephrotic syndrome. Biopsy with collapsing GN. Pt was on mTOR inhibitor and also had recent treatment with pamidronate. Both are potential etiologies.

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Interesting nephrectomy specimen with congenital nephrotic syndrome Type 1 (NPHS1 mutation). Mesangial hypercellularity, segmental sclerosis and frequent tubular microcysts.

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